Complexation of ibuprofen with water soluble p-sulfonatocalix [4]arene: a potential candidate for drug delivery application

Complexation of ibuprofen with water soluble p-sulfonatocalix[4]arene [3] was evaluated. Both molecules exhibit a host and guest type complexation. pH, complex stoichiometry and binding constant were determined by UV-Vis and FT-IR spectroscopy. The maximum complexation of 3 with ibuprofen occurs at pH 2. Stability constant values [9.897] show that there is favorable complex formed due to vital role of p-sulfonatocalix[4]arene, while the thermodynamic parameters, i.e. [Delta]G, [Delta]H and [Delta]S have been found as -24.09 KJ/mol, 0.012 KJ/mol and 0.12 KJ/mol. K, respectively. The results show that 3 has efficiency to carry the drug at particular conditions and can be used for drug delivery as a carrier

Dentists[5] perception and practices regarding primary prevention of dental caries

Aims: The primary aim of this study was to determine dentist's knowledge and practices regarding caries prevention. The secondary aim was to compare preventive practices of dentists that have not studied community and preventive dentistry, to dentists that had it included in their curriculum

Methodology: A cross-sectional study of dental practitioners of Peshawar will be carried out, using a structured, self-administered, close ended questionnaire. Responses will be collected and statistical analysis will be performed using SPSS version

Results: The majority of respondents in the study were male [51.6%] and [48.3%] were female dentists. Only 37.5% of the dentists report providing dental sealants, whereas 62.5% did not provided dental sealant treatment to their patients. Only 38% of the dentists informed their patients about the different forms of fluoride available [dietary fluoride drops/tablets and fluoride varnish]. And the dentists who informed about the different forms of fluoride only 28% among them performed pits and fissure sealing. The lowest level of understanding was regarding caries risk assessment [CRA] and availability of oral health awareness material for patients

Conclusion: Dentists' lack of understanding of dental caries prevention impacts not only their clinical decision-making but also what they tell their patients. The results of this study recommend that there is a need to enhance the level of awareness of dentist regarding the practice of preventive dentistry. In order to effectively reduce the burden of oral diseases and especially prevent early childhood caries